{"product_id":"human-tumor-necrosis-factor-receptor-superfamily-member-14-tnfrsf14-elisa-kit-96t","title":"Human Tumor Necrosis Factor Receptor Superfamily Member 14, TNFRSF14 ELISA Kit, 96T","description":"\u003cp\u003eReceptor for four distinct ligands: The TNF superfamily members TNFSF14\/LIGHT and homotrimeric LTA\/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed: 9462508, PubMed: 10754304, PubMed: 18193050, PubMed: 23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed: 19915044, PubMed: 9153189, PubMed: 9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14\/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed: 10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed: 23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed: 18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed: 19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed: 19915044) (By similarity). (Microbial infection) Acts as a receptor for Herpes simplex virus 1\/HHV-1. (Microbial infection) Acts as a receptor for Herpes simplex virus 2\/HHV-2.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592720920949,"sku":"BT-E6641Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-tumor-necrosis-factor-receptor-superfamily-member-14-tnfrsf14-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}