{"product_id":"human-ubiquitin-conjugating-enzyme-e2-variant-1-ube2v1-elisa-kit-96t","title":"Human Ubiquitin-conjugating Enzyme E2 Variant 1, UBE2V1 ELISA Kit , 96T","description":"\u003cp\u003eHas no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7\/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I\/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed: 31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592716726645,"sku":"BT-E6376Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/human-ubiquitin-conjugating-enzyme-e2-variant-1-ube2v1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}