{"product_id":"ksr-1phospho-ser392-polyclonal-antibody-50ul","title":"Ksr-1(Phospho Ser392) Polyclonal Antibody, 50ul","description":"\u003cp\u003eThe sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.,PTM:Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated.,Belongs to the protein kinase superfamily. TKL Ser\/Thr protein kinase family.,Contains 1 phorbol-ester\/DAG-type zinc finger.,Contains 1 protein kinase domain.,subcellular location:In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.,subunit:Interacts with HSPCA\/HSP90, YWHAB\/14-3-3, CDC37, MAP2K\/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK\/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515824681333,"sku":"BT-AP10762-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/de\/products\/ksr-1phospho-ser392-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}