{"product_id":"latphospho-tyr255-rabbit-polyclonal-antibody-20ul","title":"LAT(Phospho Tyr255) Rabbit Polyclonal Antibody, 20ul","description":"\u003cp\u003eRequired for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling| both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores| PKC activation| MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1| GRB2| GRAP2| and other signaling molecules.|miscellaneous:Engagement of killer inhibitory receptors (KIR) disrupts the interaction of PLCG1 with LAT and blocks target cell-induced activation of PLC| maybe by inducing the dephosphorylation of LAT.|PTM:Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.|PTM:Phosphorylated on tyrosines by ZAP-70 upon TCR activation| or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement.|subcellular location:Present in lipid rafts.|subunit:When phosphorylated| interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2| GRAP| GRAP2| PLCG1 and PLCG2. Interacts indirectly with CBL| SOS| VAV| and LCP2. Interacts with SHB| SKAP2 and CLNK (By similarity). Interacts with FCGR1A.|tissue specificity:Expressed in thymus| T-cells| NK cells| mast cells and| at lower levels| in spleen. Present in T-cells but not B-cells (at protein level).|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56517225513333,"sku":"BT-AP11001-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_3.jpg?v=1766971577","url":"https:\/\/www.labcart.com\/de\/products\/latphospho-tyr255-rabbit-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}