{"product_id":"lats1-2-polyclonal-antibody-50ul","title":"LATS1\/2 Polyclonal Antibody, 50ul","description":"\u003cp\u003eSerine\/threonine-protein kinase LATS1\/2 encoded by LATS1 is a putative serine\/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2\/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514031288693,"sku":"BT-AP04966-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/de\/products\/lats1-2-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}