{"product_id":"lats1phospho-thr1079-rabbit-polyclonal-antibody-50ul","title":"LATS1(Phospho-Thr1079) Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eThe protein encoded by this gene is a putative serine\/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner| with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity| indicating a role as a negative regulator of CDC2\/cyclin A. In addition| the C-terminal kinase domain binds to its own N-terminal region| suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas| ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514940338549,"sku":"BT-AP11010-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/lats1phospho-thr1079-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}