BT LAB

Artikelnummer: BT-E0021Mo-96T

Mouse Interleukin 11, IL-11 ELISA Kit, 96T

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed: 8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed: 22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed: 10026196, PubMed: 23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed: 23948300, PubMed: 22253262). The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (By similarity).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:0.43ng/L

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Features and Capabilities

Application:ELISA

Detection Target:IL11

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Detection Range: 1-300ng/L

Research Areas:Immunology

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Reactivity:Mouse

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Test Principle:Sandwich

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Assay Time:1h 30m

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