{"product_id":"mouse-programmed-cell-death-1-ligand-1-cd274-elisa-kit-96t","title":"Mouse Programmed Cell Death 1 Ligand 1, CD274 ELISA Kit, 96T","description":"\u003cp\u003ePlays a critical role in induction and maintenance of immune tolerance to self (PubMed: 11238124). As a ligand for the inhibitory receptor PDCD1\/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed: 11238124). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed: 11015443, PubMed: 12719480). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival (PubMed: 12218188, PubMed: 27281199). The interaction with PDCD1\/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (PubMed: 12218188). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy (PubMed: 12218188).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592846618997,"sku":"BT-E2363Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/mouse-programmed-cell-death-1-ligand-1-cd274-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}