{"product_id":"nse2-polyclonal-antibody-50ulbt-ap12036","title":"NSE2 Polyclonal Antibody, 50ul[BT-AP12036]","description":"\u003cp\u003eE3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.,pathway:Protein modification; protein sumoylation.,PTM:Sumoylated, possibly via autosumoylation.,Belongs to the NSE2 family.,Contains 1 SP-RING-type zinc finger.,subunit:Component of the SMC5-SMC6 complex which consists of SMC5, SMC6, NSMCE2\/MMS21 and probably NSMCE1.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515925049717,"sku":"BT-AP12036-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/de\/products\/nse2-polyclonal-antibody-50ulbt-ap12036","provider":"LabCart Life Science","version":"1.0","type":"link"}