{"product_id":"p40-phoxphospho-thr154-polyclonal-antibody-50ul","title":"p40-phox(Phospho Thr154) Polyclonal Antibody, 50ul","description":"\u003cp\u003eThe protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2\/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1\/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding d\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515942121845,"sku":"BT-AP12647-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/p40-phoxphospho-thr154-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}