{"product_id":"pdk1phospho-ser241-polyclonal-antibody-20ul","title":"PDK1(Phospho Ser241) Polyclonal Antibody, 20ul","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB\/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine\/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,Belongs to the protein kinase superfamily.,Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. PDK1 subfamily.,Contains 1 PH domain.,Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56508783886709,"sku":"BT-AP07524-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_3.jpg?v=1766971577","url":"https:\/\/www.labcart.com\/de\/products\/pdk1phospho-ser241-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}