{"product_id":"pen2-rabbit-polyclonal-antibody-50ul","title":"PEN2 Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003ePresenilins| which are components of the gamma-secretase protein complex| are required for intramembranous processing of some type I transmembrane proteins| such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides| the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling| and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515527475573,"sku":"BT-AP11874-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/pen2-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}