BT LAB

Artikelnummer: BT-PHS00536-100ul

Phospho-Ataxin-1 (S776) Polyclonal Antibody, 100ul

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: aDCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the pure cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 40-83 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for ATXN1 (ataxin 1).

€247,50 EUR
€247,50 EUR
2-4 weeks
Hassle-Free Warranty
Safe & Secure Payment
Livetime Tech Support
  • Specification
  • Downloads
  • Reviews
€247,50
ADD TO CART
ADD TO CART

Product Specification

Basic Information

Brands:BT LAB

Model Number:

Place of Origin:China

Warranty:

Safety Performance:

Protection Class:

Sterile Status:

Reconstitution:

Shipping:

Battery:

Battery Service Life:

Component:

Technical Specifications

Capacity:

Concentration:1 mg/ml

Dimension [D×W×H]:

Diameter:

Length:

Width:

High:

Volume:

Volume Range:

Speed:

Speed Range:

Max.Speed:

Max. RCF:

Temperature Range:

Operating Temperature Range:

Permissible Ambient Temperature :

Permissible Relative Humidity:

Input voltage:

Power Requirements:

Voltage/Frequency:

Sensitivity:

Specificity:

Precision:

Speed Accuracy:

Volume Accuracy:

Particle Size:

Pore Size:

Binding Capacity:

Calculated Molecular Weight:

Observed Molecular Weight:

Purity:

Shelf Life:

Storage:-20°C for 1 year

Random Error:

Acceleration/Braking time:

Aspiration Speed:

Calculated Molecular Weight:

Dilution:

Driving Motor DC motor:

Em:

Ex:

Endotoxin:

Flow rate [liquid]:

Features and Capabilities

Application:WB, IHC-p, IF, ELISA

Detection Target:ATXN1

Detection Type:

Detection Range:

Research Areas:Epigenetics and Nuclear Signaling; Neuroscience

Species Reactivity:

Reactivity:Human, mouse

Target Synonym:

Test Principle:

Quantitative/Qualitative :

Result Type:

Materials :

Assay Time:

Autoclave component:

Available Rotor Adapters:

Binding Capacity:

Bio-activity:

Bottom Shape:

Bottom Type:

Buffer:

Cap Color:

Clonality:Polyclonal

Conjugation:

Coupled Ligand:

Cover Type:

Detection Instrument :

Dispensing Speed:

Display:

Form:

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Graduation:

Growth Area:

Download File