{"product_id":"phospho-caspase-1-s376-polyclonal-antibody-50ul","title":"Phospho-Caspase-1 (S376) Polyclonal Antibody, 50ul","description":"\u003cp\u003eCASP1 (caspase 1) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. CASP1 has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514543124853,"sku":"BT-PHS00749-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_6.jpg?v=1768209536","url":"https:\/\/www.labcart.com\/de\/products\/phospho-caspase-1-s376-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}