{"product_id":"phospho-pkc-theta-y90-rabbit-polyclonal-antibody-50ul","title":"Phospho PKC theta (Y90) Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|The C1 domain| containing the phorbol ester\/DAG-type region 1 (C1A) and 2 (C1B)| is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.|enzyme regulation:Three specific sites; Thr-538 (activation loop of the kinase domain)| Ser-676 (turn motif) and Ser-695 (hydrophobic region)| need to be phosphorylated for its full activation.|PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters| a class of tumor promoters.|This is a calcium-independent| phospholipid-dependent| serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation| but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production.|PTM:Autophosphorylation at Thr-219 is required for targeting to the TCR and cellular function of PKC upon antigen receptor ligation.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. PKC subfamily.|Contains 1 AGC-kinase C-terminal domain.|Contains 1 C2 domain.|Contains 1 protein kinase domain.|Contains 2 phorbol-ester\/DAG-type zinc fingers.|subunit:Interacts with TXNL2\/PICOT.|tissue specificity:Skeletal muscle| megakaryoblastic cells and platelets.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515528687989,"sku":"BT-AP11925-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/phospho-pkc-theta-y90-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}