{"product_id":"presenilin-1phospho-ser357-polyclonal-antibody-20ul","title":"Presenilin 1(Phospho Ser357) Polyclonal Antibody, 20ul","description":"\u003cp\u003eAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56513206976885,"sku":"BT-AP13299-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon4_b9646263-7fda-4fd2-82e8-9047834a0edb.jpg?v=1767148117","url":"https:\/\/www.labcart.com\/de\/products\/presenilin-1phospho-ser357-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}