BT LAB

Artikelnummer: BT-AP04321-50ul

PSME1 Rabbit Polyclonal Antibody, 50ul

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes| a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base| which contains 6 ATPase subunits and 2 non-ATPase subunits| and a lid| which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome| the immunoproteasome| is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator| referred to as the 11S regulator or PA28| that replaces the 19S regulator. Three subunits (alpha| beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator| one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Concentration:1 mg/ml

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Storage:-20°C for 1 year

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Application:WB

Detection Target:PSME1

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Research Areas:Cell biology; Microbiology

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Reactivity:Human, Mouse, Rat

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Clonality:Polyclonal

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Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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