{"product_id":"pttg1-2-3-polyclonal-antibody-50ul","title":"PTTG1\/2\/3 Polyclonal Antibody, 50ul","description":"\u003cp\u003ePituitary tumor-transforming 1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. PTTG1 product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. PTTG1 contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. PTTG1 product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for PTTG1.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514344911221,"sku":"BT-AP07507-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_6.jpg?v=1768209536","url":"https:\/\/www.labcart.com\/de\/products\/pttg1-2-3-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}