Artikelnummer: E-AB-62995_120μL-ES

PTTG1 Polyclonal Antibody, 120 μL

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.

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Produktspezifikation

Grundlegende Informationen

Marken: Elabscience

Versand: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Speicher: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Haltbarkeit: 12 months

Herkunftsort: China

Technical Specifications

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Concentration:1mg/mL

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Calculated Molecular Weight:22kDa

Observed Molecular Weight:24kDa

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Shelf Life:12 months

Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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Calculated Molecular Weight:22kDa

Dilution:WB 1:500-1:2000;IHC 1:100-1:200

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Konzentration: 1mg/mL

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Anwendung: WB;IHC

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