BT LAB

Artikelnummer: BT-E1083Ra-96T

Rat Nuclear Factor Erythroid 2-related Factor 2, NRF2 ELISA Kit, 96T

Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed: 16314513). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (By similarity). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (By similarity). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (By similarity).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:0.07ng/ml

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Application:ELISA

Detection Target:NFE2L2

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Detection Range: 0.2-60ng/ml

Research Areas:Others

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Test Principle:Sandwich

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Assay Time:1h 30m

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