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Artikelnummer: E-AB-90920_200μL-ES
SPRY3 Polyclonal Antibody, 200 μL
Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich carboxy-terminal domain with their Drosophila counterparts. Sprouty proteins are cytoplasmic in unstimulated cells, but in cells stimulated by growth factors they anchor to the plasma membrane by palmitoylation. Sprouty 1 and 2 associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on serine residues. Sprouty 2 can associate with c-Cbl, a downregulator of RTK signaling, and inhibit the activities of several growth factors. Unlike the widely expressed Sprouty members 1, 2 and 4, Sprouty 3 expression is restricted to adult brain and testis. Sprouty 4 is a target of the WNT/b-catenin signaling pathway in progenitor cells. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.
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Produktspezifikation
Grundlegende Informationen
Marken: Elabscience
Versand: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Speicher: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Haltbarkeit: 12 months
Herkunftsort: China
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Concentration:1mg/mL
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Calculated Molecular Weight:31kDa
Observed Molecular Weight:36kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:31kDa
Dilution:WB 1:500-1:2000
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Konzentration: 1mg/mL
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