BT LAB

Artikelnummer: BT-AP08954-100ul

TFIIH p44 Polyclonal Antibody, 100ul

GTF2H2 is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. GTF2H2 is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Concentration:1 mg/ml

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Storage:-20°C for 1 year

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Features and Capabilities

Application:WB, IHC-p, IF, ELISA

Detection Target:GTF2H2

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Research Areas:Epigenetics and Nuclear Signaling

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Reactivity:Human, Mouse, Rat

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Clonality:Polyclonal

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Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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