{"product_id":"vhl-polyclonal-antibody-50ulbt-ap15472","title":"VHL Polyclonal Antibody, 50ul[BT-AP15472]","description":"\u003cp\u003eVon Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G\/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56516100751733,"sku":"BT-AP15472-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/de\/products\/vhl-polyclonal-antibody-50ulbt-ap15472","provider":"LabCart Life Science","version":"1.0","type":"link"}