{"product_id":"ask1phospho-thr838-rabbit-polyclonal-antibody-50ul","title":"ASK1(Phospho Thr838) Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eCatalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838| inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to| and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.|Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6| which in turn activate the JNK and p38 MAP kinases| respectively. Overexpression induces apoptotic cell death.|induction:By TNF-alpha. Inhibited by HIV-1 Nef.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. STE Ser\/Thr protein kinase family. MAP kinase kinase kinase subfamily.|Contains 1 protein kinase domain.|subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.|tissue specificity:Abundantly expressed in heart and pancreas.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514736324981,"sku":"BT-AP06104-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_6.jpg?v=1768209536","url":"https:\/\/www.labcart.com\/products\/ask1phospho-thr838-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}