{"product_id":"c-ablphospho-tyr412-rabbit-polyclonal-antibody-50ul","title":"c-Abl(Phospho-Tyr412) Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eThis gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes| including cell division| adhesion| differentiation| and response to stress. The activity of the protein is negatively regulated by its SH3 domain| whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias| most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants| which contain alternative first exons that are spliced to the remaining common exons. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514760147317,"sku":"BT-AP06658-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_6.jpg?v=1768209536","url":"https:\/\/www.labcart.com\/products\/c-ablphospho-tyr412-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}