{"product_id":"cd63-polyclonal-antibody-100ulbt-ap02257","title":"CD63 Polyclonal Antibody, 100ul[BT-AP02257]","description":"\u003cp\u003eNLRP3 encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. NACHT LRR and PYD domains-containing protein 3 interacts with the apoptosis-associated speck-like protein PYCARD\/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56516235985269,"sku":"BT-AP02257-100ul","price":247.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/products\/cd63-polyclonal-antibody-100ulbt-ap02257","provider":"LabCart Life Science","version":"1.0","type":"link"}