{"product_id":"centaurin-beta-1-rabbit-polyclonal-antibody-20ul","title":"Centaurin-beta 1 Rabbit Polyclonal Antibody, 20ul","description":"\u003cp\u003ePH domain binds phospholipids including phosphatidic acid| phosphatidylinositol 3-phosphate| phosphatidylinositol 3|5-bisphosphate (PIP2) and phosphatidylinositol 3|4|5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.|enzyme regulation:GAP activity stimulated by phosphatidylinositol 4|5-bisphosphate (PIP2) and phosphatidic acid.|GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.|miscellaneous:Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.|PTM:Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1| export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.|Contains 1 Arf-GAP domain.|Contains 1 BAR domain.|Contains 1 PH domain.|Contains 3 ANK repeats.|subunit:Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4\/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1.|tissue specificity:Highest level in lung and spleen. Low level in heart| kidney| liver and pancreas.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56517014520181,"sku":"BT-AP07513-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_3.jpg?v=1766971577","url":"https:\/\/www.labcart.com\/products\/centaurin-beta-1-rabbit-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}