{"product_id":"collagen-xviii-alpha-1cleaved-his1572-rabbit-polyclonal-antibody-50ul","title":"Collagen XVIII alpha 1(Cleaved-His1572) Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eThis gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins| extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin| a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities| so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514821816693,"sku":"BT-AP08259-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/products\/collagen-xviii-alpha-1cleaved-his1572-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}