{"product_id":"cxxc4-rabbit-polyclonal-antibody-50ul","title":"CXXC4 Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eThis gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless\/integrated signaling pathway. The encoded protein negatively regulates wingless\/integrated signaling through interaction with the post synaptic density protein\/ Drosophila disc large tumor suppressor\/ zonula occludens-1 protein domain of Dishevelled| a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition| the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides| localize to promoters and CpG islands| and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2| an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans| a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514835480949,"sku":"BT-AP08822-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/products\/cxxc4-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}