{"product_id":"dok-3-polyclonal-antibody-50ul","title":"Dok-3 Polyclonal Antibody, 50ul","description":"\u003cp\u003eDok-1, Dok-2 and Dok-3 are members of a class of \"docking\" proteins which contain multiple tyrosine residues and putative SH2 binding sites. Dok-1 associates with the Ras GTPase activating protein (Ras GAP) upon tyrosine phosphorylation. Dok-2 (also designated p56 Dok) has also been identified as a potential mediator of the effects of p210 Bcr-Abl. Dok-3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of Dok-3. Upon phosphorylation, Dok-3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk. Dok-3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56513654620533,"sku":"BT-AP02699-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/products\/dok-3-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}