{"product_id":"her2phospho-tyr1139-polyclonal-antibody-20ul","title":"HER2(Phospho-Tyr1139) Polyclonal Antibody, 20ul","description":"\u003cp\u003eThis gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654\/Ile655| shown here. Amplification and\/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56516992074101,"sku":"BT-AP06593-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon4_b9646263-7fda-4fd2-82e8-9047834a0edb.jpg?v=1767148117","url":"https:\/\/www.labcart.com\/products\/her2phospho-tyr1139-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}