{"product_id":"human-25-hydroxyvitamin-d-1-alpha-hydroxylase-mitochondrial-cyp27b1-elisa-kit-96t","title":"Human 25-Hydroxyvitamin D-1 Alpha Hydroxylase, Mitochondrial, CYP27B1 ELISA Kit, 96T","description":"\u003cp\u003eA cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3\/calcidiol at the C1alpha-position to form the hormonally active form of vitamin D3, 1alpha,25-dihydroxyvitamin D3\/calcitriol that acts via the vitamin D receptor (VDR) (PubMed: 10518789, PubMed: 9486994, PubMed: 22862690, PubMed: 10566658, PubMed: 12050193). Has 1alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway (PubMed: 10518789, PubMed: 22862690). Converts 24R,25-dihydroxyvitamin D3\/secalciferol to 1-alpha,24,25-trihydroxyvitamin D3, an active ligand of VDR. Also active on 25-hydroxyvitamin D2 (PubMed: 10518789). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via FDXR\/adrenodoxin reductase and FDX1\/adrenodoxin (PubMed: 22862690).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592540598645,"sku":"BT-E3868Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-25-hydroxyvitamin-d-1-alpha-hydroxylase-mitochondrial-cyp27b1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}