{"product_id":"human-actin-related-protein-3-actr3-elisa-kit-96t","title":"Human Actin-related Protein 3, ACTR3 ELISA Kit, 96T","description":"\u003cp\u003eATP-binding component of the Arp2\/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed: 9000076). The Arp2\/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed: 9000076). Seems to contact the pointed end of the daughter actin filament (PubMed: 9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed: 29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2\/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed: 17220302, PubMed: 29925947). The Arp2\/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed: 29925947). Plays a role in ciliogenesis (PubMed: 20393563).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592609050997,"sku":"BT-E4623Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-actin-related-protein-3-actr3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}