{"product_id":"human-alpha-synuclein-snca-elisa-kit-96t","title":"Human Alpha-Synuclein, SNCA ELISA Kit , 96T","description":"\u003cp\u003eNeuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed: 28288128, PubMed: 30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed: 30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha\/DNAJC5 (PubMed: 20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed: 20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed: 26442590).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592483418485,"sku":"BT-E1313Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-alpha-synuclein-snca-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}