{"product_id":"human-c-x-c-chemokine-receptor-type-3-cxcr3-elisa-kit-96t","title":"Human C-X-C Chemokine Receptor Type 3, CXCR3 ELISA Kit, 96T","description":"\u003cp\u003e[Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed: 12782716). Binds to CCL21. Probably promotes cell chemotaxis response. [Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed: 12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. [Isoform 3]: Mediates the activity of CXCL11.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592762143093,"sku":"BT-E7269Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-c-x-c-chemokine-receptor-type-3-cxcr3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}