{"product_id":"human-catenin-beta-1-ctnnb1-elisa-kit-96t","title":"Human Catenin Beta 1, CTNNB1 ELISA Kit, 96T","description":"\u003cp\u003eKey downstream component of the canonical Wnt signaling pathway (PubMed: 17524503, PubMed: 18077326, PubMed: 18086858, PubMed: 18957423, PubMed: 21262353, PubMed: 22155184, PubMed: 22647378, PubMed: 22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed: 17524503, PubMed: 18077326, PubMed: 18086858, PubMed: 18957423, PubMed: 21262353, PubMed: 22155184, PubMed: 22647378, PubMed: 22699938). In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF\/LEF family, leading to activate Wnt responsive genes (PubMed: 17524503, PubMed: 18077326, PubMed: 18086858, PubMed: 18957423, PubMed: 21262353, PubMed: 22155184, PubMed: 22647378, PubMed: 22699938). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion (PubMed: 18086858). Involved in the CDK2\/PTPN6\/CTNNB1\/CEACAM1 pathway of insulin internalization (PubMed: 21262353). Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 (PubMed: 18957423). Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed: 22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF\/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592500261237,"sku":"BT-E2396Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-catenin-beta-1-ctnnb1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}