{"product_id":"human-coiled-coil-domain-containing-protein-47-ccdc47-elisa-kit-96t","title":"Human Coiled-Coil Domain-containing Protein 47, CCDC47 ELISA Kit , 96T","description":"\u003cp\u003eComponent of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes (PubMed: 32814900). The PAT complex acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins (PubMed: 32814900). WDR83OS\/Asterix is the substrate-interacting subunit of the PAT complex, whereas CCDC47 is required to maintain the stability of WDR83OS\/Asterix (PubMed: 32814900). The PAT complex favors the binding to TMDs with exposed hydrophilic amino acids within the lipid bilayer and provides a membrane-embedded partially hydrophilic environment in which the first transmembrane domain binds (PubMed: 32814900). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed: 32820719). Involved in the regulation of calcium ion homeostasis in the ER (PubMed: 30401460). Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (PubMed: 25009997). Has an essential role in the maintenance of ER organization during embryogenesis (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592652697973,"sku":"BT-E5065Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-coiled-coil-domain-containing-protein-47-ccdc47-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}