{"product_id":"human-cyclin-dependent-kinase-inhibitor-1-cdkn1a-elisa-kit-96t","title":"Human Cyclin-dependent Kinase Inhibitor 1, CDKN1A ELISA Kit, 96T","description":"\u003cp\u003eMay be involved in p53\/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed: 11595739). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed: 9106657).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592524411253,"sku":"BT-E3243Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-cyclin-dependent-kinase-inhibitor-1-cdkn1a-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}