{"product_id":"human-cytochrome-p450-1a2-cyp1a2-elisa-kit-96t","title":"Human Cytochrome P450 1A2, CYP1A2 ELISA Kit, 96T","description":"\u003cp\u003eA cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed: 9435160, PubMed: 10681376, PubMed: 11555828, PubMed: 12865317, PubMed: 19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed: 9435160, PubMed: 10681376, PubMed: 11555828, PubMed: 12865317, PubMed: 19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed: 11555828, PubMed: 12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed: 11555828, PubMed: 12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed: 21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed: 10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed: 19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed: 9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed: 21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed: 14725854). Metabolizes caffeine via N3-demethylation (Probable).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592497869173,"sku":"BT-E2281Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-cytochrome-p450-1a2-cyp1a2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}