{"product_id":"human-cytochrome-p450-2c9-cyp2c9-elisa-kit-96t","title":"Human Cytochrome P450 2C9, CYP2C9 ELISA Kit, 96T","description":"\u003cp\u003eA cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed: 7574697, PubMed: 9866708, PubMed: 9435160, PubMed: 12865317, PubMed: 15766564, PubMed: 19965576, PubMed: 21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed: 7574697, PubMed: 9866708, PubMed: 9435160, PubMed: 12865317, PubMed: 15766564, PubMed: 19965576, PubMed: 21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed: 7574697, PubMed: 15766564, PubMed: 19965576, PubMed: 9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed: 21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed: 12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed: 9866708, PubMed: 9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed: 11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed: 25994031).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592655090037,"sku":"BT-E5160Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-cytochrome-p450-2c9-cyp2c9-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}