{"product_id":"human-gamma-aminobutyric-acid-type-b-receptor-subunit-2-gabbr2-elisa-kit-96t","title":"Human Gamma-aminobutyric Acid Type B Receptor Subunit 2, GABBR2 ELISA Kit, 96T","description":"\u003cp\u003eComponent of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed: 9872316, PubMed: 9872744, PubMed: 15617512, PubMed: 18165688, PubMed: 22660477, PubMed: 24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed: 18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed: 10075644, PubMed: 10773016, PubMed: 24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium Channels, inactivates voltage-dependent calcium-Channels and modulates inositol phospholipid hydrolysis (PubMed: 10075644, PubMed: 9872744, PubMed: 10906333, PubMed: 10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed: 9872744, PubMed: 22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium Channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed: 9872316, PubMed: 10075644, PubMed: 9872744, PubMed: 22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592717578613,"sku":"BT-E6458Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-gamma-aminobutyric-acid-type-b-receptor-subunit-2-gabbr2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}