{"product_id":"human-granzymes-b-gzms-b-elisa-kit-96t","title":"Human Granzymes B, GZMS-B ELISA Kit , 96T","description":"\u003cp\u003eAbundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed: 3262682, PubMed: 3263427, PubMed: 1985927). It cleaves after Asp (PubMed: 8258716, PubMed: 1985927). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed: 32188940, PubMed: 31953257). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (PubMed: 9852092).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592478732661,"sku":"BT-E0899Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-granzymes-b-gzms-b-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}