{"product_id":"human-hla-class-2-histocompatibility-antigen-dr-alpha-chain-hla-dra-elisa-kit-96t","title":"Human Hla Class 2 Histocompatibility Antigen, Dr Alpha Chain, HLA-DRA ELISA Kit, 96T","description":"\u003cp\u003eAn alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic Peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed: 29884618, PubMed: 17334368, PubMed: 81$458.00|$300.0019, PubMed: 15322540, PubMed: 22327072, PubMed: 27591323, PubMed: 31495665, PubMed: 15265931, PubMed: 9075930, PubMed: 24190431). Typically presents extracellular Peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed: 81$458.00|$300.0019). In the tumor microenvironment, presents antigenic Peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed: 31495665). Presents Peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed: 17182262, PubMed: 23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut\/trim later' for pathogen-derived antigenic Peptides and 'cut first, bind later' for autoantigens\/self-peptides (PubMed: 25413013). The anchor residue at position 1 of the Peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed: 81$458.00|$300.0019).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592664199541,"sku":"BT-E5425Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-hla-class-2-histocompatibility-antigen-dr-alpha-chain-hla-dra-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}