{"product_id":"human-hla-class-2-histocompatibility-antigen-gamma-chain-cd74-elisa-kit-96t","title":"Human Hla Class 2 Histocompatibility Antigen Gamma Chain, CD74 ELISA Kit, 96T","description":"\u003cp\u003ePlays a critical role in MHC class II antigen processing by stabilizing Peptide-free class II alpha\/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal\/lysosomal system where the antigen processing and binding of antigenic Peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. [Class-II-associated invariant chain Peptide]: Binds to the Peptide-binding site of MHC class II alpha\/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic Peptides to the MHC class II complex until its release by HLA-DM in the endosome. [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed: 32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed: 32855215). \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592591847797,"sku":"BT-E4489Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-hla-class-2-histocompatibility-antigen-gamma-chain-cd74-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}