{"product_id":"human-interferon-induced-helicase-c-domain-containing-protein-1-ifih1-elisa-kit-96t","title":"Human Interferon-induced Helicase C Domain-containing Protein 1, IFIH1 ELISA Kit, 96T","description":"\u003cp\u003eInnate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (\u0026gt;1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS\/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Detects coronavirus SARS-CoV-2 (PubMed: 24686847). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592570941813,"sku":"BT-E4251hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-interferon-induced-helicase-c-domain-containing-protein-1-ifih1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}