{"product_id":"human-metastasis-suppressor-kiss-1-kiss1-elisa-kit-96t","title":"Human Metastasis-Suppressor Kiss-1, KISS1 ELISA Kit , 96T","description":"\u003cp\u003eMetastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated Peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine\/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1\/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592670261621,"sku":"BT-E5666Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-metastasis-suppressor-kiss-1-kiss1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}