{"product_id":"human-neurogenic-locus-notch-homolog-protein-2-notch2-elisa-kit-96t","title":"Human Neurogenic Locus Notch Homolog Protein 2, NOTCH2 ELISA Kit, 96T","description":"\u003cp\u003eFunctions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ\/RBPSUH and activates genes of the enhancer of split locus (PubMed: 21378985, PubMed: 21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA\/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed: 29149593). Positively regulates self-renewal of liver cancer cells (PubMed: 25985737).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592525885813,"sku":"BT-E3262Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-neurogenic-locus-notch-homolog-protein-2-notch2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}