{"product_id":"human-ninein-gsk3b-interacting-protein-nin-elisa-kit-96t","title":"Human Ninein\/Gsk3B Interacting Protein, NIN ELISA Kit, 96T","description":"\u003cp\u003eA-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed: 27484798, PubMed: 25920809, PubMed: 16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed: 27484798, PubMed: 16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed: 25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed: 19830702).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592523755893,"sku":"BT-E3201Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-ninein-gsk3b-interacting-protein-nin-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}