{"product_id":"human-nkg2-d-type-2-integral-membrane-protein-klrk1-elisa-kit-96t","title":"Human Nkg2-D Type 2 Integral Membrane Protein, KLRK1 ELISA Kit, 96T","description":"\u003cp\u003eFunctions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L\/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2\u0026gt;ULBP1\u0026gt;ULBP3) and ULBP4.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592563110261,"sku":"BT-E4183hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-nkg2-d-type-2-integral-membrane-protein-klrk1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}