{"product_id":"human-nlr-family-card-domain-containing-3-nlrc3-elisa-kit-96t","title":"Human Nlr Family, Card Domain Containing 3, NLRC3 ELISA Kit, 96T","description":"\u003cp\u003eNegative regulator of the innate immune response (PubMed: 15705585, PubMed: 22863753, PubMed: 25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING\/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed: 22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed: 22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1\/PIK3R2) and disrupting the association between PIK3R1\/PIK3R2 and the catalytic subunit p110 (PIK3CA\/PIK3CB\/PIK3CD) and reducing PIK3R1\/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed: 25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed: 25277106).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592721805685,"sku":"BT-E6709Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-nlr-family-card-domain-containing-3-nlrc3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}